Hi,
Tuc la minh noi chat cua ban co nhom OH, trong khi ban cung ancol cho phan ung nay, nen minh nghi no se co anh huong, ban thu lam thi nghiem xem co anh huong khong. Thuong phan ung nay nguoi ta dung EtOH voi hieu suat khoang 85-95% (kha cao). Minh gui ban 1 phan ung tuong tu de tham khao.
Synthesis of 2-Arylidenemalononitrile (4). The synthesis of
several noncommercially available intermediates 2-arylide-
nemalononitriles (4) was carried using the same reaction
conditions described for the following synthesis of 2-benzy-
lidenemalononitrile and with final yields between 85 to 95%.
Piperidine (6.25 g, 73.4 mmol) was added to a stirred
solution of benzaldehyde (7.4 g, 73.4 mmol) and malono-
nitrile (4.85 g, 73.4 mmol) in ethanol (50 mL). After stirring
overnight, the reaction mixture was concentrated in vacuum
prior to the addition of dilute HCl (200 mL, 0.1 M) and the
reaction products extracted into dichloromethane. The com-
bined extracts were dried (Na2SO4) and concentrated in
vacuum, subsequent recrystallization from dichloromethane/
hexane afforded 2-benzylidenemalononitrile (93% yield),
which was quickly taken on to the cyclization reaction
Chuc ban thanh cong
than ai
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