Article: Highly enantioselective and cis-diastereoselective cyclopropanation of olefins catalyzed by ruthenium complexes of (iminophosphoranyl)ferrocenes (Shampa)

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Highly enantioselective and cis-diastereoselective cyclopropanation of olefins catalyzed by ruthenium complexes of (iminophosphoranyl)ferrocenes

Tetrahedron Letters 48 (2007) 8014–8017

Vo D. M. Hoang, Pattubala A. N. Reddy and Tae-Jeong Kim

Abstract—Chiral (iminophosphoranyl)ferrocenes (1 and 2) are highly efficient ligands to achieve high diastereoselectivity (up to 95/5 dr in favor of the cis-isomer) as well as enantioselectivity (up to 99% ee) in Ru-catalyzed asymmetric cyclopropanation of various
olefins. Reversal in diastereoselectivity is found as a function of metal-to-ligand ratio in the reaction of styrene.

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